Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-04-01
1996-05-28
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241841, 435 723, 43524026, 5303881, 53038822, 5303888, 53038885, 530828, A61K 3900, A61K 3514, C12Q 100, G01N 3353, C12N 500, C07K 100, C07K 1400, C07K 1600, C07K 1628, C07K 1630, C07K 1700
Patent
active
055212859
ABSTRACT:
The present invention comprises the epitope recognized by the human monoclonal antibody 28A32, the human tumor antigen containing this epitope, which we have identified, isolated and characterized, and human MCA 28A32. The invention also relates to the use of antibodies to the antigen containing this epitope for diagnosis and monitoring of treatment of cancer and to the use of this antigen in the preparation of vaccines to elicit an immune response similar to that obtained against tumor cells containing this epitope.
REFERENCES:
patent: 4727021 (1988-02-01), Cote et al.
patent: 4828991 (1989-05-01), Hanna et al.
patent: 4997762 (1991-03-01), Hanna, Jr. et al.
Goldenberg et al (1976) "Antigens Associated with . . . " Cancer Res 36: 3455-3463.
Kohler et al., Nature, No. 256:495-497 (1975).
Haspel et al., Cancer Research, 45:3951-3961 (1985).
Biological Abstracts, vol. 89, No. 6, issued Mar. 15, 1990, Kitamura, K., "A New Colorectal Carcinoma Associated Antigen Recognized by Murine Monoclonal Antibody A7", Abstract No. 60871, J. Kyoto Perfect Univ Med, 1989, 98(12), 1259-1268 (Eng.).
Biological Abstracts, vol. 86, No. 7, issued Oct. 1, 1988, R. P. McCabe et al., "Preclinical Studies on the Pharmokinetic Properties of Human Monoclonal Antibodies to Colorectal Cancer and Their Use for Detection of Tumors", Abstract No. 71598, Cancer Res, 1988, 48(15), 4348-4353 (Eng.).
Biological Abstracts, vol. 87, No. 12, issued 1989, K. Kitamura et al., "Immunochemical Characterization of the Antigen Recognized by the Murine Monoclonal Antibody A7 Against Human Colorectal Cancer", Abstract No. 128049, Tohokv J. Exp Med, 157(2), 83-94 (Eng.).
Biological Abstracts, vol. 91, issued 1991, Y. Chimori et al, "Identification and Characterization of a Colon Cancer-associated Antigen Expressed on Leukemia-lymphoma Cell Lines", Abstract No. 97740, Int. J Cancer, 1991, 47(3), 426-430 (Eng).
Biochemical and Biophysical Research Communications, vol. 128, No. 1, issued Apr. 16, 1985, (Washington DC, USA), Hollmann et al., "Monoclonal Antibody-defined Circulating Human Tumor-associated Antigen with Epitope Shared by Cytokeratin", pp. 34-39.
The Journal of Immunology, vol. 137, No. 5, issued Sep. 1, 1986 (Washington DC USA), Raychaudhuri et al., "Tumor-specific Idiotype Vaccines. I. Generation and Characterization of Internal Image Tumor Antigens", pp. 1743-1749.
Science, vol. 228, issued Apr. 12, 1985 (Washington DC, USA), Marx, "Making Antibodies Without the Antigens", pp. 162-165.
Cancer Research, vol. 44, No. 12, issued Dec. 1984 (USA), Schmidt et al., "Characterization of Monoclonical Antibodies to Novikoff Hepatoma Cytokeratin Antigen p39", pp. 5867-5879.
Journal of Cellular Biochemistry, vol. 24, issued 1984 (Los Angeles, CA, USA) Franklin et al., "A Monoclonal Antibody Recognizes an Epitope Common to an Avian-specific Nuclear Antigen and to Cytokeratins", pp. 1-14.
Cancer Research, vol. 45, No. 11, issued Nov. 1985, (Bethesda, MD, USA), Koprowska et al., "Common Antigenic Sites on Exfoliated Cells Derived from Cervical Carcinoma and in Tumor Cells of Nonuterine Origin as Demonstrated by Monoclonal Antibodies in Immunoperoxidase Assay", pp. 5964-5968.
Goligher, J. C., Surgery of the Anus, Rectum and Colon, 4th ed., London: Baillere Tindall (1980) 47-471.
Gold, P. and Freedman, S. O., J. Exp. Med. (1965) 122:467-481.
Yeoman, L. C. et al., Human Colon Tumor Antigens. In: H. Busch and L. C. Yeoman (eds.), vol. 19, 231-271, New York: Academic Press, Inc. (1982).
Magnani, J. L. et al., Cancer Res. (1983) 43:5489-5492.
Artigas, C. et al., Cancer Res.(1986) 45:1874-1881.
Silverberg, E., CA (1983) 33:9-25.
Hoover, H. C., Jr. et al. Biologic Therapy of Cancer Principles and Practices. (1990) In press. J. P. Lippincott Co.
Hoover, H. C., Jr., et al. Cancer (1985) 55:1236-1243.
Blasczyk, M. et al., Cancer Res. (1984) 44:245-253.
Ross, A. H., et al., Biochem. Biophys. Res. Comm. (1986) 135:297-303.
Bos Ebo S.
Hanna, Jr. Michael G.
Pomato Nicholas
Ransom Janet H.
Akzo Nobel N.V.
Blackstone William M.
Gormley Mary E.
Minnifield Nita M.
Nucker Christine M.
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