csPCNA isoform modifications and uses thereof

Details csPCNA isoform modifications and uses thereof csPCNA isoform modifications and uses thereof

2011-04-26

2011-04-26

Goddard, Laura B (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

07932023

ABSTRACT:
Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.

REFERENCES:
patent: 2003/0162233 (2003-08-01), Malkas et al.
Bechtel et al (Cancer Research, 1998, 58:3264-3269).
Hoelz et al, Proteomics, 2006, 6:4808-4816, IDS.
Bechtel et al., “A unique form of proliferating cell nuclear antigen is present in malignant breast cells,”Cancer Res., Amer. Assoc. for Cancer Res., 58: 3264-3269 (1998).
Hoelz et al., “The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS.”Proteomics, 6(17): 4808-4816 (2006).
Malkas et al., “A cancer-specific form of proliferating cell nuclear antigen (csPCNA) is present in malignant human breast cells and tissues,”Jrnl of Clin. Ligand Assay, 25(1): 20-32 (2002).
Naryzhny et al., “Observation of multiple isoforms and specific proteolysis patterns of proliferating cell nuclear antigen in the context of cell cycle compartments and sample preparations,”Proteomics, 3(6): 930-936 (2003).

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