CS-1 peptidomimetics, compositions and methods of using the same

Details CS-1 peptidomimetics, compositions and methods of using the same CS-1 peptidomimetics, compositions and methods of using the same

1997-04-14

2000-09-12

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530330, 530331, 562571, A61K 3805

Patent

active

061178403

ABSTRACT:
The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory peptide are also disclosed.

REFERENCES:
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patent: 5294511 (1994-03-01), Furcht et al.
patent: 5294551 (1994-03-01), Furcht et al.
patent: 5340802 (1994-08-01), Shiosaki et al.
Esser and Roos, "N-Terminal Cyclization of Peptides with N, N.sup.1 -Carbonyldiimidazole or N, N.sup.1 -Thiocarbonyldiimidazole," Angew. Chem. Int. Ed. Engl. 17:467-468 (1978).
Esser and Roos, "N-Terminale Cyclisierung von Peptiden mit N, N.sup.1 -Carbonyldiimidazol oder N, N.sup.1 -Thiocarbonyldiimidazol," Angew. Chem. 90:495-496 (1978).
Galleyrand, Peptides 519, 1992.
Komoriya et al., "The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-asparic acid-valine," J. Biol. Chem. 266:15075-15079 (1991).

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