Crystals of the tyrosine kinase domain of non-insulin receptor t

Details Crystals of the tyrosine kinase domain of non-insulin receptor t Crystals of the tyrosine kinase domain of non-insulin receptor t

1996-08-21

1999-08-24

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 530350, C07K 14705, C12N 912

Patent

active

059424281

ABSTRACT:
Crystals of the tyrosine kinase domain of cytoplasmic tyrosine kinases and receptor tyrosine kinases that undergo ligand-mediated receptor dimerization are provided. In particular, crystals of a mutant of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FLGK), alone and in complex with a non-hydrolyzable adenosine triphosphate analogue, are provided. Also provided are the high resolution three dimensional structures of crystalline FLGK, both alone and in co-complex with the adenosine triphosphate analogue, as determined by X-ray diffraction.

REFERENCES:
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