Crystals of the sodium salt of pravastatin

Details Crystals of the sodium salt of pravastatin Crystals of the sodium salt of pravastatin

2006-07-18

2006-07-18

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S256000

Reexamination Certificate

active

07078558

ABSTRACT:
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, fluvastatin and cervastatin and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to anAspergillus, Monascus, Nocardia, Amycolatopsis, Mucor, orPenicilliumgenus, some are obtained by treating the fermentation products using the methods of chemical synthesis (simvastatin) or they are the products of total chemical synthesis (fluvastatin, atorvastatin and cervastatin). The present invention relates to a crystalline form of the sodium salt of pravastatin, which is known by the chemical name 1-naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, mono sodium salt, which is useful as a pharmaceutical substance. The present invention further relates to the method for its preparation and isolation, to a pharmaceutical formulation containing the sodium salt of pravastatin in the crystalline form and a pharmaceutically acceptable carrier, and to a pharmaceutical method of treatment. The novel crystalline form of the sodium salt of pravastatin is useful in the treatment of hypercholesterolemia and hyperlipidemia.

REFERENCES:
patent: 6740775 (2004-05-01), Pflaum
patent: 2002/0081675 (2002-06-01), Jekkel et al.
patent: WO 98/45410 (1998-10-01), None
patent: WO 00/17150 (2000-03-01), None
Arai et al, (1988) Annu. Rep. Sankyo, 40, pp. 1-38.
Harry G. Brittain , Polymorphism in Pharmaceutical Solids, Marcel Dekker, Inc. 1999, p. 236, lines 17-22.
Sato et al, The Jrnl of Antibiotics vol. XLI, No. pp. 126567 (1988).
Arai et al, Pravastatin Sodium(CS 5145)—A Novel Cholesterol Lowering Agent Which Inhibits HMG-CoA Reductase (1988).

Affiliated with

Also associated with

Rating

Crystals of the sodium salt of pravastatin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystals of the sodium salt of pravastatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystals of the sodium salt of pravastatin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3590898