Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2001-02-06
2002-09-03
Huang, Evelyn Mei (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S191000, C546S203000, C514S316000, C514S325000
Reexamination Certificate
active
06444821
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to crystals of N-(2(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride, intermediates for production of the same, and a process for producing the same.
2. Description of the Background
N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride, hereinafter referred to as Compound (I) at times has the formula (I):
and exhibits anti-hypertensive activity as well as activity in controlling platelet agglutination. Thus, this compound is useful in pharmaceutical preparations. However, crystals thereof are as yet unknown.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride.
It is also an object of the present invention to provide an intermediate compound for preparing the compound of the formula (I).
It is, moveover, an object of the present invention to provide a process for producing the compound of the formula (I).
The above objects and others are provided by crystals of N-(2-(4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride monohydrate.
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Fox et al., “Physics and chemistry of the organic solid state” Interscience Pub. p. 223-224, 1963.*
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Asai Koji
Fujii Akiko
Kubo Mie
Mihara Ryuichi
Naora Hirokazu
Ajinomoto Co. Inc.
Huang Evelyn Mei
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