Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
1996-10-23
2001-02-06
Chang, Ceila (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S325000, C546S191000, C546S203000
Reexamination Certificate
active
06184233
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to crystals of N-(2(4-(5 H-dibenzo [a,d]cyclohepten-5-ylidene)piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride, intermediates for production of the same, and a process for producing the same.
2. Description of the Background
N-(2-(4-(5H-dibenzo [a,d]cyclohepten-5-ylidene)-piperidino)ethyl)- 1-formyl-4-piperidinecarboxamide hydrochloride, hereinafter referred to as Compound (I) at times has the formula (I)
and exhibits anti-hypertensive activity as well as activity in controlling platelet agglutination. Thus, this compound is useful in pharmaceutical preparations. However, crystals thereof are as yet unknown.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide crystals of N-(2-(4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride.
It is also an object of the present invention to provide an intermediate compound for preparing the compound of the formula (I).
It is, moveover, an object of the present invention to provide a process for producing the compound of the formula (I).
The above objects and others are provided by crystals of N-(2-(4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride monohydrate.
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Fox et al. “Physics and chemistry of the organic solid state” Interscience Pub. p.223-224, 1963.
Evans “Crystal chemistry” Cambridge Pre. p.354-355, 393-396, 1964.
Fox et al. “Physics and chemistry of organic solids” Interscience pub. p. 181, 1963.
Asai Koji
Fujii Akiko
Kubo Mie
Mihara Ryuichi
Naora Hirokazu
Ajinomoto Co. Inc.
Chang Ceila
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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