Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-09-29
2001-05-15
Chang, Ceila (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S191000
Reexamination Certificate
active
06232323
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to crystals of N-(2(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride, intermediates for production of the same, and a process for producing the same.
2. Description of the Background
N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride, hereinafter referred to as Compound (I) at times has the formula (I):
and exhibits anti-hypertensive activity as well as activity in controlling platelet agglutination. Thus, this compound is useful in pharmaceutical preparations. However, crystals thereof are as yet unknown.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride.
It is also an object of the present invention to provide an intermediate compound for preparing the compound of the formula (I).
It is, moveover, an object of the present invention to provide a process for producing the compound of the formula
The above objects and others are provided by crystals of N-(2-(4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride monohydrate.
REFERENCES:
patent: 5932593 (1999-08-01), Makino et al.
Asai Koji
Fujii Akiko
Kubo Mie
Mihara Ryuichi
Naora Hirokazu
Ajinomoto Co. Inc.
Chang Ceila
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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