Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalani

Details Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalani Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalani

1993-12-14

1996-01-30

Henley, III, Raymond

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C23900

Patent

active

054881501

ABSTRACT:
Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, eg. stability to grinding.

REFERENCES:
patent: 196222 (1886-01-01), Toyoshima et al.
patent: 4816484 (1989-03-01), Toyoshima et al.
Diabetes Research and Clinical Practice, 12 (1991) 53-60 "Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[Trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals" Yusuke Sato, Masahiko Nishikawa, Hisashi Shinkai and Eiji Sukegawa, Central Research Laboratories, Ajinomoto Co. Inc., Life Sciences Laboratories, Yokohama, Japan.

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