Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylala

Details Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylala Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylala

1994-02-02

1995-10-31

Henley, III, Raymond

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562444, 562445, C07C22900

Patent

active

054631165

ABSTRACT:
Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, e.g., stability to grinding.

REFERENCES:
patent: 4650785 (1987-03-01), Toyoshima et al.
patent: 4670584 (1987-06-01), Toyoshima et al.
patent: 4816484 (1989-03-01), Toyoshima et al.
Yusuke Sato, Masahiko Nishikawa, Hisashi Shinkai and Eiji Sukegawa, Diabetes Research and Clinical Practice, vol. 12 (1991) "Possibility of ideal blood glucose by a new oral hyopglycemic agent, N-[(trans-4-isopropycyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals" pp. 53-59.

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