Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Reexamination Certificate
2007-03-20
2007-03-20
Steadman, David J. (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
Reexamination Certificate
active
10696011
ABSTRACT:
The invention relates to crystals of an insulin analog in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring neutral or acidic amino acid residue, where phenylalanine (Phe) in position B1 of the B chain can optionally be absent, the crystals being present in the space group R3 (No. 146) with the cell axes A=81.5 ű1 Å and C=33.3 ű1 Å, their preparation and use, and a pharmaceutical composition comprising these crystals.
REFERENCES:
patent: 4644057 (1987-02-01), Bicker et al.
patent: 5101013 (1992-03-01), Dorschug et al.
patent: 5358857 (1994-10-01), Stengelin et al.
patent: 5473049 (1995-12-01), Obermeier et al.
patent: 5663291 (1997-09-01), Obermeier et al.
patent: 6221633 (2001-04-01), Ertl et al.
patent: 6310038 (2001-10-01), Havelund
patent: 6818738 (2004-11-01), Havelund
patent: 0 214 826 (1987-03-01), None
patent: 0 375 437 (1990-06-01), None
patent: 0 419 504 (1991-04-01), None
patent: 0 678 522 (1995-10-01), None
patent: 0709395 (1996-05-01), None
patent: WO 98/42749 (1998-10-01), None
patent: WO 02/076495 (2002-10-01), None
Giege et al. Crystallogenesis of Biological Macromolecules: Facts and Perspectives. Acta Cryst., (1994) D50. pp. 339-350.
Wittingham et al. X-ray Crystallographic Studies on Hexameric Insulins in the Presence of Helix-Stabilizing Agents, Thiocyanate, Methlyparaben, and Phenol. Biochemistry. 1995. vol. 34, pp. 15553-15563.
Drenth, J. “Principles of Protein X-Ray Crystallography”, 2nd Edition, 1999 Springer-Verlag New York Inc., Chapter 1, pp. 1-19.
Weber, P.C. Overview of Protein Crystallization Methods. Methods in Enzymology, 1997, vol. 276, pp. 13-22.
Baker, E.N., et. al., The Structure Of 2Zn Pig Insulin Crystals At 1.5 A Resolution, Phil. Trans. R. Soc. Land, (1998), vol. 319, pp. 369-456.
Bentley, G.A., et. al., Role Of B13 Glu In Insulin Assembly; The Hexamer Structure Of Recombinant Mutant (B13 Glu Gln) Insulin, Journal Of Molecular Biology, (1992), vol. 228, pp. 1163-1176.
Berger M., et. al., Towards More Physiological Insulin Therapy In the 1990s, Diabetes Research and Clinical Practice, (1989), vol. 6, pp. S25-S31.
Bernstein, F.C., et. al. , The Protein Data Bank: A Computer-Based Archival File For Macromolecular Structures, Journal Of Molecular Biology, (1977), vol. 112, pp. 535-542.
Bolli, G.B., et. al., The Pharmacokinetic Basis Of Insulin Therapy In Diabetes Mellitus, Diabetes Research and Clinical Practice, (1989), vol. 6, pp. S3-S16.
Brange, J., et. al., Neutral Insulin Solutions Physically Stabilized By Addition Of Zn2+, Diabetic Medicine, (1986), vol. 3, pp. 532-536.
Dixon, G.H., et. al., Regeneration Of Insulin Activity From The Separated And Inactive A and B Chains, Nature, (1960), vol. 188, No. 4752, pp. 721-724.
Drury, P.L., et. al., Diabetic Nephropathy, British Medical Bulletin, (1989), vol. 45, No. 1, pp. 127-147.
Home, P.D., et. al., Insulin Treatment: A Decade Of Change, British Medical Bulletin, (1989), vol. 45, No. 1, pp. 92-110.
Kang, S., et. al., Subcutaneous Insulin Absorption Explained By Insulin's Physicochemical Properties Evidence From Absorption Studies Of Soluble Human Insulin And Insulin Analogues in Humans, Diabetes Care, (1991), vol. 14, No. 11, pp. 942-948.
Kemmler, W., et. al., Studies On The Conversion Of Proinsulin To Insulin, The Journal Of Biological Chemistry, (1971), vol. 246, No. 22, pp. 6786-6791.
Kohner, E.M., et. al., Diabetic Retinopathy, British Medical Bulletin, (1989), vol. 45, No. 1, pp. 148-173.
Marshall, R.C., et. al., Protein Oligomer Composition, Preparation of Monomers and Constituent Chains, Practical Protein Chemistry—A Handbook (1986) S. 49-53.
The Diabetes Control And Complications Trial Research Group, The Effect Of Intensive Treatment Of Diabetes On The Development And Progression Of Long-Term Complications In Insulin-Dependent Diabetes Mellitus, The New England Journal Of Medicine, (1993), vol. 218, No. 14, pp. 977-986.
Ward, J.D., et. al., Diabetic Neuropathy, British Medical Bulletin, (1989), vol. 45, No. 1, pp. 111-126.
Nelligan Mark C.
Sanofi-Aventis Deutschland GmbH
Steadman David J.
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