Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1990-04-27
1993-09-14
Naff, David M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435219, C12N 964, C12N 950
Patent
active
052448002
ABSTRACT:
Crystals of human complement factor D that are triclinic are disclosed. They are made by a method of crystallization known as the "hanging drop" technique. The technique uses 1.0-1400 mM NaCl and polyethylene glycol maintained at a pH of 5.2-7.0, more preferably 5.3-6.1.
REFERENCES:
Volanakis et al., Isolation of Complement Protein D . . . Analytical Biochemistry, 163, pp. 242-246, 1987.
Atkins, Pysical Chemistry, Third edition, pp. 550-557, 1986.
Barnum et al., Quantitation of Complement Factor . . . , J. of Immunological Methods, 67, pp. 303-309, 1984.
Rosen et al., Adipsiu and Complement Factor D . . . , Science, vol. 244, pp. 1483-1487, Jun. 1989.
Niemann et al., The Use of Monoclonal Antibodies as . . . , J. of Immunology, vol. 132, No. 2, pp. 809-815, 1984.
Laemmli et al., Cleavage of Structural Proteins During . . . , Nature, vol. 227, pp. 680-685, 1970.
Vogt et al., Mechanisms of Complement Activation . . . , Molecular Immunology, vol. 22, No. 2, pp. 101-106, 1985.
Giege et al., J. of Crystal Growth, vol. 90, p. 374, 1988.
Einspahv et al., J. of Crystal Growth Crystallization of Recombinant Human I(1B), pp. 180-187, vol. 90, 1988.
Volanakis, J. et al., The New England Journal Of Medicine 312:395-399 (1985).
DeLucas, L. J. and Bugg, C. E., Tibtech, vol. 5:188-192 (Jul. 1987).
DeLucas, L. J. et al., Journal Of Crystal Growth 76:681-693 (1986).
Phipps, D. J. and Aston, W. P., Vet. Immunol. Immunopathol. 19 (3-4):251-258 (1988) (abstract).
Sharf, R. et al., Biochemistry 27 (8):2990-2997 (1988) (abstract).
Takada, A. et al., Complement 4 (2):110 (1987) (abstract).
Chandrashekar R. et al., Exp. Parasitol. 62 (3):362-369 (1986) (abstract).
Pasechnik. V. A., J. Chromatogr. 364P:359-368 (1986) (abstract).
Menger, M. and Aston, W. P., Vet. Immunol. Immunopathol. 7 (3-4):325-336 (1984) (abstract).
Blanchard, D. B. and Leid, R. W., Mol. Immunol. 21 (10):869-876 (1984) (abstract).
Niemann, M. A. et al., J. Immunol. 132 (2):809-815 (1984) (abstract).
Soliakov, L. S. and Kozlov, L. V., Bioorg. Khim. 9 (4):462-469 (1983) (abstract).
Truedsson, L. and Sturfelt, G., J. Immunol. Methods 63 (2) 207-214 (1983) (abstract).
Minta, J. O. and Gee, A. P., Methods Enzymol. 93P:375-408 (1983) (abstract).
DeLucas Lawrence J.
Volanakis John E.
Meller Michael
Naff David M.
The UAB Research Foundation
LandOfFree
Crystals of human complement factor D that are triclinic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystals of human complement factor D that are triclinic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystals of human complement factor D that are triclinic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2025938