Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
1999-04-30
2008-10-21
Allen, Marianne P (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S007100, C435S183000, C514S002600, C514S012200
Reexamination Certificate
active
07438920
ABSTRACT:
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
REFERENCES:
patent: WO 97/12043 (1997-04-01), None
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Caron Paul
Kim Joseph L.
Lin Chao
Morgenstern Kurt
Allen Marianne P
Haley Jr. James F.
Ropes & Gray LLP
Vertex Pharmaceuticals Incorporated
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