Crystals of etanercept and methods of making thereof

Details Crystals of etanercept and methods of making thereof Crystals of etanercept and methods of making thereof

2007-10-02

2007-10-02

Bragdon, Kathleen Kerr (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C436S004000

Reexamination Certificate

active

10901735

ABSTRACT:
The present invention relates to crystalline etanercept and to methods of making crystalline etanercept; to pharmaceutical compositions comprising crystalline etanercept; and to therapeutic uses of such compositions.

REFERENCES:
patent: 5945397 (1999-08-01), Smith et al.
Drenth, “Principles of Protein X-Ray Crystallography”, 2nd Edition, 1999 Springer-Verlag New York Inc., Chapter 1, p. 1-21.
Giege et al. Crystallogenesis of Biological Macromolecules: Facts and Perspectives, Acta Cryst. D., 1994, D50:339-350.
Cudney, Protein Crystallization and Dumb Luck, Rigaku Journal, 1999, 16(1):1-7.
“ENBREL For Subcutaneous Injection” information pamphelet available from the United States FDA at http://www.fda.gov/medwatch/safety/2005/jul—PI/Enbrel—PI.pdf.
Goffe, B. and J.C. Cather, Etanercept: An Overview,J. Am. Acad. Dematol. 49:S105-11 (2003).
Jen, A. and H.P. Merkle, “Diamonds in the Rough: Protein Crystals from a Formulation Perspective,”Pharm. Res. 18(11):1483-1488 (2001).
Park, Y.C. et al., “Structural basis for self-association and receptor recognition of human TRAF2,”Nature398:533-538 (1999).
Scallon, B. et al., “Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists,”J. Pharmacol. Exp. Ther. 301(2):418-426 (2002).
Yang, M.X. et al., “Crystalline monoclonal antibodies for subcutaneous delivery,”Proc. Natl. Acad. Sci. USA 100(12):6934-6939 (2003).
International Search Report, PCT/US2004/024738,mailed Jan. 7, 2005.

Affiliated with

Also associated with

Rating

Crystals of etanercept and methods of making thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystals of etanercept and methods of making thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystals of etanercept and methods of making thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3888571