Crystallization process of quetiapine hemifumarate

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S551000

Reexamination Certificate

active

08044038

ABSTRACT:
The present invention relates to a process for preparing crystalline quetiapine hemifumarate, which comprises crystallizing or re-crystallizing quetiapine hemifumarate from a mixture of water and a water soluble alcohol.

REFERENCES:
patent: 6372734 (2002-04-01), Snape et al.
patent: 0 240 228 (1987-10-01), None
patent: WO-01/55125 (2001-08-01), None
patent: WO-03/080065 (2003-10-01), None
patent: WO-2004/076431 (2004-09-01), None
Ravikumar et al., “Quetiapine hemifumarate,” Acta Crystallographica Section E: Structure Reports, vol. E61, No. 10, 2005, pp. 3245-3248.

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