Crystallization process

Details Crystallization process Crystallization process

1980-03-03

1981-11-03

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 22, C07D50112

Patent

active

042987326

ABSTRACT:
A process for the preparation of crystalline sodium cefuroxime (the sodium salt of (6R,7R)-3-carbamoyloxymethyl-7-[(Z)-2-(fur-2-yl)-2-methoxyimino-acetamido] ceph-3-em-4-carboxylic acid) which comprises adding an aqueous solution of sodium cefuroxime and an aqueous solution containing sodium ions to an aqueous crystallizing medium containing a seeding amount of solid sodium cefuroxime and recovering crystalline sodium cefuroxime from the crystalline medium. The process enables the production of crystalline sodium cefuroxime on an industrial scale in a condition of sufficient sterility, purity and solid state stability for use in pharmaceutical preparations.

REFERENCES:
patent: 3714154 (1973-01-01), Pfeiffer et al.
patent: 3974153 (1976-08-01), Cook et al.
Murthy et al., "Organic Chemistry Made Simple", (1962), p. 258.
Ault, "Techniques and Experiments for Organic Chemistry", (1976), pp. 53 & 90.

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