Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1998-02-02
1999-04-27
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
530344, 530419, 530420, C07K 130, C07K 132, C07K 1462
Patent
active
058980679
ABSTRACT:
A method of providing zinc containing crystals of a protein derivative which has a lysine residue which carries a lipophilic substituent on the .epsilon.-amino group, said method comprising providing a solution of the protein derivative in an alkaline buffer, which further contains a zinc salt, adjusting the pH value of the solution to a value between 7 and 10, and isolating the crystals formed.
REFERENCES:
patent: 3856771 (1974-12-01), Jackson
patent: 3884897 (1975-05-01), Geiger et al.
patent: 3907763 (1975-09-01), Brandenburg et al.
patent: 4959351 (1990-09-01), Grau
patent: 5008241 (1991-04-01), Markussen et al.
patent: 5028586 (1991-07-01), Balschmidt et al.
patent: 5461031 (1995-10-01), De Felippis
patent: 5700904 (1997-12-01), Baker et al.
patent: 5750497 (1998-05-01), Havelund et al.
Whittingham et al, Crystal Structure of a Prolonged-Acting . . . Biochemistry. vol. 36, pp. 2826-2831, Mar. 11, 1997.
Balschmidt Per
Whittingham Jean Lesley
Esq. Reza Green
Gregg, Esq. Valeta
Novo Nordisk A S
Russel Jeffrey E.
Zelson Esq. Steve T.
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