Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2008-05-06
2008-05-06
Steadman, David J. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C436S004000, C702S027000
Reexamination Certificate
active
07368269
ABSTRACT:
Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.
REFERENCES:
patent: 1 321 518 (2003-06-01), None
patent: WO 03/054180 (2003-07-01), None
Giege et al. Crystallogenesis of Biological Macromolecules: Facts and Perspectives, Acta Cryst. D., 1994, D50:339-350.
McPherson, A. Current Approaches to Macromolecular Crystallization. European Journal of Biochemistry. 1990. vol. 189, pp. 1-23.
Kundrot, C.E. Which Strategy for a Protein Crystallization Project? Cellular Molecular Life Science. 2004. vol. 61, pp. 525-536.
Cudney R. Protein Crystallization and Dumb Luck. The Rigaku Journal. 1999. vol. 16, No. 1, pp. 1-7.
Drenth, “Principles of Protein X-Ray Crystallography”, 2nd Edition, 1999 Springer-Verlag New York Inc., Chapter 1, p. 1-21.
Appendix A—Sequence alignment of amino acids 61-388 of SEQ ID No. 1 and amino acids 55-400 of SEQ ID No. 4 from Ohren et al. (WO 03/054180). No date.
Cronin Ciaran N.
Dougan Douglas R.
Knuth Mark W.
Kraus Michelle L.
Lim Kheng
Noakes Suzanne M.
Smith C. Amy
Steadman David J.
Takeda San Diego, Inc.
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