Crystallization of iodixanol using milling

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C424S009452, C216S052000

Reexamination Certificate

active

07999134

ABSTRACT:
This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling.

REFERENCES:
patent: 5525328 (1996-06-01), Bacon et al.
patent: 2008/0287711 (2008-11-01), Strandmyr

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