Crystallization of ibuprofen

Details Crystallization of ibuprofen Crystallization of ibuprofen

1983-07-25

1984-10-09

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5142

Patent

active

044762488

ABSTRACT:
Ibuprofen is crystallized from a .delta.H.gtoreq.8 liquid such as a C.sub.1 to C.sub.3 -alkanol, e.g., methanol, containing solutions thereof to obtain ibuprofen crystals which are equant (cube, sphere or grain) in shape, which ibuprofen crystals have larger average partile size, higher bulk density, lower bulk volume and improved flow properties compared to previously known bulk ibuprofen crystalline materials.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 4189596 (1980-02-01), VanRheenen
Kirk-Othmer-Encyclopedia of Chem. Technology, 2nd Edit., (Supp. vol.), John Wiley & Sons, (1971), 889-910.
Derwent Abstract 38877x/21 of Japan 5 1041-338 dated Apr. 7, 1976.
Derwent Abstract 38878x/21 of Japan 5 1041-339 dated Apr. 7, 1976.

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