Crystallization of chemical species/polymorphs and...

Details Crystallization of chemical species/polymorphs and... Crystallization of chemical species/polymorphs and...

2009-09-03

2011-11-08

Warden, Jill (Department: 1773)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Reexamination Certificate

active

08053242

ABSTRACT:
The crystallization of chemical species/polymorphs comprises forming droplets of a solution of a substance with optionally different concentrations of said substance in an inert phase; producing and storing the droplets in at least one storage microchannel (1); forming crystals in all droplets; increasing the temperature in order to induce the dissolution of at least a portion of the crystals in at least some droplets; and analyzing the crystallization and dissolution process.

REFERENCES:
patent: 7214540 (2007-05-01), DeLucas et al.
patent: 2005/0129580 (2005-06-01), Swinehart et al.
patent: 2006/0137597 (2006-06-01), David
patent: 2007/0052781 (2007-03-01), Fraden et al.
patent: 2907228 (2008-04-01), None
Garcia et al., “Crystallization and dissolution of pharmaceutical compounds: An experimental approach”, Journal of Crystal Growth, 198/199, 1360-1364 (1999).

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