Crystallization of c-KIT tyrosine kinase leading to...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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C435S194000, C702S027000

Reexamination Certificate

active

10651494

ABSTRACT:
Provided are crystals relating to the autoinhibited structure of c-KIT tyrosine kinase (c-KIT) and its various uses.

REFERENCES:
patent: 2004/0137518 (2004-07-01), Lambert et al.
patent: WO 01/16181 (2001-03-01), None
Brunger, Axel T. et al., “Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination”, Acta Cryst. (1998) D54, pp. 905-921.
Creighton, Thomas E. et al., Encyclopedia of Molecular Biology, vol. 1, New York, 1999, pp. 586 and 2725.
Drenth, Jan, “Principles of Protein X-ray Crystallography”, Springer, New York, 1995, p. 1.
Hegyi, Heidi et al., “The Relationship between Protein Structure and Function: a Comprehensive Survey with Application to the Yeast Genome”, J. Mol. Biol. (1999) 288, 147-164.
Kierzek, Andrzej M. et al., Biophysical Chemistry, “Models of protein crystal growth”, (2001), pp. 1-20.
Mol, Clifford et al., Accelerated Publication, “Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation”, The Journal of Biological Chemistry, vol. 278, No. 34, Aug. 2003, pp. 31461-31464.
Tooze, John et al., “Introduction to Protein Structure” Second Edition; Garland Publishing Inc., New York, (1999), pp. 373-375.
Wiencek, J.M. , “New Strategies for Protein Crystal Growth”, Ann. Review Biomed. Enginr 1999, 1, pp. 505-536.

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