Crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl est

Details Crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl est Crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl est

1996-06-28

1998-03-31

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

560 41, A61K 3800, C07C22900

Patent

active

057338833

ABSTRACT:
Improved method for crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester (aspartame) from an aqueous solution by conductive cooling while avoiding turbulence in the crystallizing system wherein crystallization is carried out with cooling to a temperature level not lower than 10.degree. C. in the presence of at least 0.1% by weight of a C.sub.3-8 ketone, the amount of ketone and the temperature level being chosen for each individual ketone so that a homogeneous solvent system is present at the start of crystallization and an open drainable network of aspartame crystals is obtained.

REFERENCES:
patent: 4962222 (1990-10-01), Mita et al.
patent: 5298648 (1994-03-01), Ebisawa et al.
Hatada et al, J. Amer. Chem. Soc. 107 4279-82 (1985).

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