Crystallization and purification of macrolides

Details Crystallization and purification of macrolides Crystallization and purification of macrolides

2007-06-19

2007-06-19

Kunemund, Robert (Department: 1722)

Single-crystal, oriented-crystal, and epitaxy growth processes;

Processes of growth from liquid or supercritical state

Having growth from a solution comprising a solvent which is...

C117S069000, C117S070000, C117S924000, C117S926000

Reexamination Certificate

active

10815339

ABSTRACT:
Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent at pH of 7 or above.

REFERENCES:
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4160861 (1979-07-01), Cole et al.
patent: 4543334 (1985-09-01), Celmer et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5116756 (1992-05-01), Dumont et al.
patent: 5200505 (1993-04-01), Takesako et al.
patent: 5496727 (1996-03-01), Okuhara et al.
patent: 5506233 (1996-04-01), Hauske et al.
patent: 5508398 (1996-04-01), Gletsos
patent: 5622866 (1997-04-01), Motamedi et al.
patent: 5624842 (1997-04-01), Okuhara et al.
patent: 6387258 (2002-05-01), Keri et al.
patent: 2002/0128470 (2002-09-01), Fuenfschilling et al.
patent: 2003/0166924 (2003-09-01), Keri et al.
patent: 2004/0050782 (2004-03-01), Fuenfschilling et al.
patent: 2004/0266703 (2004-12-01), Keri et al.
patent: 692 839 (2002-11-01), None
patent: 2121517 (1972-11-01), None
patent: 0 184 162 (1986-06-01), None
patent: 0 652 219 (1995-05-01), None
patent: 1 234 833 (2002-08-01), None
patent: WO 92/18506 (1992-10-01), None
patent: WO 00/33878 (2000-06-01), None
Patent Abstract of Japan Publication No. 02016662; Publication date Jan. 19, 1990; Akashi Kazuya “Substituting Terminal Controller”.
Surjit S. Sengha, Fermentation, in Kirk Othmer Encyclopedia of Chemical Technology, vol. 10, p. 361-381 (Jacquiline I. Kroschwitz, editor, 4th ed. 1993).
The Merck Index, Maryadele J. O'Neil et al. eds., “Pirnecrolimus”, p. 1331, 13th ed. 2001.
Martindale: The complete drug reference, Sean C. Sweetman ed., “Sirolimus”, p. 568, Pharmaceutical Press 33rd ed. 2002.
C.E.M. Griffiths “Ascomycin: An Advance in the Management of Atopic Dermatitis” British J. of Dermatology, V. 144, p. 679-681, (2001).
Martindale: The compete drug reference, Sean C. Sweetman ed., “Everolimus”, p. 539, Pharmaceutical Press 33rd ed. 2002.
Zhiguo Song et al. “Highly Chemoselective Trichloracetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725” J. Org. Chem. 1999, v. 64, p. 1859-1867.
Jun'ichi Kobayashi et al. “Amphidinolides T2, T3, and T4, New 19-Membered Macrolides from theDinoflagellate amphidiniumsp. and the Biosynthesis of Amphidinolide T1” J. Org. Chem. 2001, v. 66, p. 134-142.
K. Yoshii et al. “Liquid Chromatographic Determination of Emamectin, Milbemectin, Invermectin and Abamectin in Crops and Confirmation by Liquid Chromatography—Mass Spectrometry” Journal of Chromatography A, v. 896, 2000, p. 75-85.

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