Crystalline vitamin D derivative

Details Crystalline vitamin D derivative Crystalline vitamin D derivative

1997-02-24

1999-05-11

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A01N45/00

Patent

active

059028068

ABSTRACT:
A crystalline (5Z,7E,23S)-26,26,26,27,27,27-hexafluoro-9,10-secocholesta-5,7,10(19)-trie n-1.alpha.,3.beta.,23,25-tetraol monohydrate has an excellent preservation stability, and is therefore useful as a medicine for treating or preventing bone diseases, tumor or psoriasis.

REFERENCES:
patent: 5030626 (1991-07-01), Hamma et al.
XP-002068116, Proceedings of the Workshop on Vitamin D, Honda et al., "Metabolism of 1,25-Dihydroxyvitamin D.sub.3 and 26,26,26,27,27,27,-Hexafluoro-1, 25-Dihydroxyvitamin D.sub.3 in HL-60 Cells," vol. 8, pp. 217-218, 1991.
J. Steroid Biochem. Molec. Biol. vol. 41, No. 1, pp. 109-112, 1992.
The Journal of the Osaka City Medical Center, vol. 42, No. 1, Mar. 1993, pp. 59-72.
The Japanese-United States Congress of Pharmaceutical Sciences, M03-Y-15(1987).
Komouro et al., Disposition and metabolism of ST-630. Yakubutsu Dotai, 1996, vol. 11, pp. 518-529, 1996.
Komouro et al., Disposition and metabolism of ST-630, Yakubutsu Dotai, 1996, vol. 11, pp. 530-540, 1996. vit D3 and vitamin D3 derivatitives, Bioorg. Med. Chem. Lett., 1996, vol. 6, pp. 1431-1436, 1996.
Tanaka et al. Colon cancer and vitamin D, Seikagaku, 1996, vol. 68, pp. 214-219, 1996.

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