Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-08-02
2005-08-02
Barts, Samuel (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
Reexamination Certificate
active
06924393
ABSTRACT:
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
REFERENCES:
patent: 4611078 (1986-09-01), Husbands et al.
patent: WO 00/32555 (2000-06-01), None
patent: WO 02/36542 (2002-05-01), None
patent: WO 02/46140 (2002-06-01), None
J.P. Yardley, et al., 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine Derivatives: Synthesis and Antidepressant Activity, Journal of Medicinal Chemistry, 1990, 33, pp. 2899-2905.
Daniel Vega et al., 1-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]dimethyl-ammonium chloride (venlafaxine hydrochloride), Acta Crystallographica Section C Crystal Structure Communications, 2000, C56, pp. 1009-1010.
Aronhime Judith
Dolitzky Ben-Zion
Nisnevich Gannady A.
Wizel Shlomit
Barts Samuel
Kenyon & Kenyon
Teva Pharmaceutical Industries Ltd.
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