Crystalline trimetrexate salts and the process for making the sa

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544291, A61K 31505, C07D23995

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active

06017921&

ABSTRACT:
The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.

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patent: 5716960 (1998-02-01), Kennedy
Robinson, C., 1994, "Trimetrexate glucuronate", Drugs of Today 30(5):347-355.
Hempel, A. et al., 1988, "Trimetrexate: Molecular structures and conformational similarities in two crystal forms", Cancer Biochem. Biophys. 10(1):25-30 .
Sutton, P.A. & Cody, V., 1987, "Conformational Analysis of Antineoplastic Antifolates: The Crystal Structure of Trimetrexate and the Aminopterine Derivative 4-[N-[2,4-Diamino-6-pteridinyl)methyl]amino]benzoic Acid", J. Med. Chem. 30:1843-1848.
Cell cycle effects of trimextrexate (CI-898), Cancer Chemotherapy and Pharmacology, Hook et al., vol. 16, No. 2, 1986, pp. 116-120 (1985).

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