Crystalline trimetrexate salts and the process for making the sa

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544291, A61K 31495, C07D23995

Patent

active

057169608

ABSTRACT:
The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.

REFERENCES:
patent: 4376858 (1983-03-01), Colbry
patent: 4853221 (1989-08-01), Elslager et al.

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