Crystalline Tiagabine monohydrate, its preparation and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546212, C07D40914, A61K 31445

Patent

active

053547608

ABSTRACT:
The invention provides crystalline Tiagabine hydrochloride monohydrate, process for its preparation, compositions containing the same and its therapeutic use as anti-epileptic agent.

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Pertwee et al., Neuropharmacology, vol. 27, No. 12, pp. 1265-1270 (1988).
Braestrup et al., Int. Congr. Ser.-Exerpta. Med. (Pharmacology), pp. 125-128 (1987).
Rustum et al., J. Chromatography, vol. 503, pp. 115-125 (1990).
Rekling et al., Br. J. Pharmacol. (1990), 99, pp. 103-106.

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