Crystalline solid form of...

Details Crystalline solid form of... Crystalline solid form of...

2006-02-14

2006-02-14

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

06998503

ABSTRACT:
(2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid is crystallized as an anhydrous, stoichiometric 1.5 HCl salt and a scaleable crystallization method is disclosed. The salt form was characterized and the absolute configuration of the chiral center was confirmed as “S”. (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid was high melting and appears acceptably non-hygroscopic for use in a pharmaceutical composition.

REFERENCES:
patent: 5854251 (1998-12-01), Hallinan et al.
patent: 5945408 (1999-08-01), Webber et al.
patent: WO 93/13055 (1993-07-01), None
patent: WO 95/25717 (1995-09-01), None
patent: WO 02/22562 (2002-03-01), None
patent: WO 02/22562 (2002-03-01), None
patent: WO 02/076395 (2002-10-01), None
McInnes et al; J. Exp. Med; 184; 1519; 1996.
Lundberg et al; Lancet; 344; 1673; 1994.
Hamid et al; Lancet; 342; 1510; 1993.
Harold, Mohr, & Tamm; Helvetica Chimica Acta; 66; 2; 744-754; 1983.

Affiliated with

Also associated with

Rating

Crystalline solid form of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystalline solid form of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline solid form of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3682658