Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate

Details Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate

1999-05-19

2000-09-12

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C22912

Patent

active

061180203

ABSTRACT:
Dodecyl 2-(N,N dimethylamino)-propionate (DDAIP) is prepared by transesterification of ethyl 2-(N,N-dimethylamino) propionate. Crystalline acid addition salts of DDAIP are prepared by cooled mixing of DDAIP with one of a select group of acids in the presence of a water immiscible solvent such as hexane. The resulting DDAIP salts are crystalline, and exhibit a pattern of defined detection peaks upon analysis by powder x-ray diffraction.

REFERENCES:
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Chemical Means of Transdermal Drug Permeation Enhancement in Transdermal and Topical Drug Delivery Systems, Ghosh T. K., Pfister W.R., Yum S.I. (Eds.), Interpharm Press Inc., Buffalo Grove, IL (1997).
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Article, "Synthesis and Enhancing Effect of Dodecyl 2-(N,N-Dimethylamino)propionate on the Transepidermal Delivery of Indomethacin, Clonidine, and Hydrocortisone", Buyuktimkin, N., et al., pp. 1632-1637, appearing in "Pharmaceutical Research," vol. 10, No. 11, 1993.
Abstract No. 2686, 1997 AAPS Annual Meeting Contributed Papers Abstracts, American Association Of Pharmaceutical Scientists.
Kirk-Othmer Encyclopedia of Chemical Technology, 4th ed., vol. 9, John Wiley & Sons, NY, 1994, pp. 774-776.

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