Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2

Details Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2 Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2

1986-12-19

1988-06-14

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514210, 536 72, 544355, C07D40312, A61K 31425, A61K 3171, C07H 1708

Patent

active

047512202

ABSTRACT:
In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M.sup..sym.=erythromycin.H.sup..sym.) salt or the dicholine (M.sup..sym. =HOCH.sub.2 CH.sub.2 N.sup..sym. (CH.sub.3).sub.3) salt of the acid (M.sup..sym. =H.sup..sym.) having the formula ##STR1## that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3- azetidinyl]-amino]-2-oxoethylidene]amino]oxy]acetic acid.

REFERENCES:
patent: 4337197 (1982-06-01), Gordon et al.
patent: 4533660 (1985-08-01), Gordon et al.
patent: 4638061 (1987-01-01), Slusarchyk
Floyd et al., "Journal of Organic Chemistry", 47:5160 (1982).
Slusarchyk et al., "Heterocycles", 21:191 (1984).
Tanaka et al., paper #854 presented at XXVI Interscience Conference on Antimicrobial Agents and Chemotherapy, Sep. 28, 1986.

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