Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-01
2011-03-01
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S114000
Reexamination Certificate
active
07897613
ABSTRACT:
The present invention relates to novel crystalline forms of the platelet aggregation inhibitor (+)-(S)-methyl-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the form of hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. The present invention further relates to processes for preparing such forms, pharmaceutical compositions comprising such forms, and uses for such forms and compositions. The pharmaceutical compositions may be used, in particular, for inhibiting platelet aggregation or for treating, preventing or managing thrombosis, atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardial infarction, non-Q-wave myocardial infarction, atherosclerosis, peripheral arterial disease, or unstable angina. The present invention also relates to methods of treating said disorders. Formula (1).
REFERENCES:
patent: 4847265 (1989-07-01), Badore et al.
patent: 6117866 (2000-09-01), Bondinell et al.
patent: 6180793 (2001-01-01), Bakonyi et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6429210 (2002-08-01), Bousquet et al.
patent: 0 281 459 (1988-07-01), None
patent: WO 03/066637 (2003-08-01), None
patent: WO 2005/068471 (2005-07-01), None
patent: WO 2005/103058 (2005-11-01), None
Umemura et al., Thrombosis research, (Nov. 1, 1995) vol. 80, No. 3, pp. 209-216.
Mino R. Caira, “Crystalline Polymorphism of Organic Compounds,”Topics in Current Chemistry, vol. 198, pp. 163-208 (1998).
“PLAVIX,” Monthly Index of Medical Specialties, Aug. 2003, p. 72.
Loscalzo, et al., “Thrombosis and Hemorrhage”, 3rded., 2003, pp. 933-935.
Arul Ramakrishnan
Gadakar Maheshkumar
Gray Jason
Pise Abhinay
Rao Rajesh
Generics [UK] Limited
Rahmani Niloofar
Seaman D. Margaret
Wolf Greenfield & Sacks P.C.
LandOfFree
Crystalline polymorphs of clopidogrel does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystalline polymorphs of clopidogrel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline polymorphs of clopidogrel will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2632214