Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-06-26
2007-06-26
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S268100, C546S276700
Reexamination Certificate
active
10755066
ABSTRACT:
A crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG.1, or which exhibits a differential scanning calorimtery profile substantially the same as that shown in FIG.3, and is represented by the formula for Compound 2:and processes for preparing Compound 2 are disclosed.Pharmaceutical compositions comprising the polymorph of the bisulfate salt and at least one excipient or carrier, and methods of using the polymorph of Compound 2 to treat a variety of physiological disorders, such as thrombosis, are also disclosed.
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Hsieh, Y. et.al.; “Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromato-graphy/tandem mass spectrometry”; Rapid Comm. in Mass Spectometry;2002;16: 944-950.
Bernatowicz, M.; “Dev. of Potent Thrombin Receptor Antagonist peptides”, J. Med. Chem.; 1996, 39, 4879-4887.
Desai Rita
Reinhardt Gerard E.
Schering Corporation
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