Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-03-13
1989-05-16
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540315, 540336, A61K 3143, C07D49932
Patent
active
048310255
ABSTRACT:
The present invention relates to a crystalline hydrate of a salt of the antimicrobial agent 1,1-dioxopenicillanoyloxymethyl 6-(D-.alpha.-amino-.alpha.-phenylacetamido)penicillanate with p-toluenesulfonic acid, more particularly the mono- and dihydrate.
The hydrates are easily obtained in a crystalline state devoid of organic solvent residues, they show good stability on storage, they are effectively absorbed and hydrolyzed in vivo, and they are thus specifically suitable for medical treatment of patients, in particular for oral administration.
REFERENCES:
patent: 4244951 (1981-01-01), Bigham
Daehne Welf von
Godtfredsen Wagn O.
Clarke Vera C.
Killos Paul J.
Leo Pharmaceutical Products Ltd.
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