Crystalline of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S258100

Reexamination Certificate

active

07138521

ABSTRACT:
The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid.

REFERENCES:
patent: 4997838 (1991-03-01), Akimoto et al.
patent: 5106974 (1992-04-01), Akimoto et al.
patent: 5344932 (1994-09-01), Taylor
patent: 5416211 (1995-05-01), Barnett et al.
patent: 6013828 (2000-01-01), Kjell et al.
Brittain “Polymorphism in pharmaceutical solids” Marcel Dekker (1999) p. 2, 185.
Evans R. C. “An introduction to crystal chemistry” Cambridge (1964) p. 284-285, 393-396.
US Pharcopia #23, National formulary #18 (1995) p. 1843-1844.
Cheronis N>D> “Semimicro experimental organic chemistry” (1958) p. 31-37.
Kirk-Othmer Encyclop0edia of chemical technology, p. 1-7, ebook section crystallization (2005).
Britten et al. “Activity of the multitargeted . . . ” CA 131:67810 (1999).
Calvert, AH; Walling, JM, “Clinical Studies with MTA,” retrieved from STN, Database Accession No. 129:310246, Abstract XP-002160356.
Gangjee, et al., “Design, Synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase . . . ”, J. Med. Chem., 2000, vol. 43, No. 21, 3837-3851.
Calvert, AH; Walling, JM, “Clinical studies with MTA”, Br. J. Cancer, 1998, vol. 78, Supp. 3, 35-40.
Barnett, Charles J. et al: A Practical Synethesis of Multitargeted Antifolate LY231514,Organic Process Research&Development, vol. 3, pp. 184-188 (1999).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Crystalline of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystalline of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3643789

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.