Crystalline n-(s-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-al

Details Crystalline n-(s-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-al Crystalline n-(s-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-al

1989-02-21

1992-08-04

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

530333, 530338, C07K 110, C07K 508

Patent

active

051360209

ABSTRACT:
A process and intermediates for the manufacture of S-3-methylheptanoic acid from S-citronellol; a novel crystalline form of immunoregulatory N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, an immunoregulatory agent; and an improved process and intermediates therefor.

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patent: 4767743 (1988-08-01), Rizzi
Morrison et al., Organic Chemistry, 1959, page 126.
Poulson et al., Organic Chemistry, 1980, pp. 1025-1031.
Herberman et al., eds. 13th International Congress of Chemotherapy, 1983, pp. 203/19-203/35.
Chemical Abstracts, v. 47, abstract No. 9268d (1953); abstracting Gol'mov, Zhur. Obshchei Khim., v. 22, 1944-53 (1952).
Eschinazi, J. Org. Chem., v. 26, 3072-3076 (1961).
House, "Modern Synthetic Reactions", 2nd ed., Benjamin, Inc., (1972) pp. 263, 269, 274-275.
LeBel et al., J. Org. Chem., v. 36, pp. 2440-2448 (1971).

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