Crystalline L-carnosine zinc complex having antiulcer activity

Details Crystalline L-carnosine zinc complex having antiulcer activity Crystalline L-carnosine zinc complex having antiulcer activity

1988-07-20

1991-01-01

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548101, 548104, A61K 31555, C07F 306, C07D22364

Patent

active

049818465

ABSTRACT:
A novel crystalline L-carnosine zinc complex is produced by reacting L-carnosine, a zinc salt and an alkali metal compound in an anhydrous or hydrous polar organic solvent.
The crystalline L-carnosine zinc complex substantially corresponds to the formula C.sub.9 H.sub.12 N.sub.4 O.sub.3 Zn and has physical properties clearly different from the known amorphous L-carnosine zinc complex.
As compared with the amorphous complex, the crystalline complex is very low in impurity, stable to heat and moisture, and easy to filtrate, and has higher anti-ulcer activity.

REFERENCES:
Weitzel et al., Hoppe-S-Z. Physiol. Chem., 307, 23, (1957).

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