Crystalline Inha Enzyme-NADH Complex

Details Crystalline Inha Enzyme-NADH Complex Crystalline Inha Enzyme-NADH Complex

1995-06-16

1996-09-17

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

117927, C12N 902, C30B 2958

Patent

active

055567789

ABSTRACT:
The crystallized complex of NADH and Inha enzyme from Mycobacterium tuberculosis is presented. Methods of designing inhibitors to the Inha enzyme and subsequent treatment with those inhibitors of infection by M. tuberculosis are disclosed.

REFERENCES:
Dessen et al. (1995) Science, 267, "Crystal Structure and Function of the Isoniazid Target of Mycobacterium tuberculosis", pp. 1638-1641.
King (10 Apr. 1989) Chem. Eng. News, pp. 32-54.
Banerjee et al. (1994) Science, 263, 227-230.

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