Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1985-07-03
1987-06-09
Hazel, Blondel
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 85, 435811, C07K 1526, A61K 4502, C12P 2100
Patent
active
046721088
ABSTRACT:
The crystallization of human leukocyte interferon is described. In a preferred embodiment crystalline recombinant human leukocyte interferon A (IFL-rA) is prepared.
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Nagata, S., et al., Nature, vol. 284, pp. 316-320, 1980.
Rubenstein, M., et al., Proc. Natl. Acad. Sci., vol. 76, pp. 640-644, 1979.
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Goeddel et al., Nature, vol. 287, pp. 411-415, 1980.
Staehelin et al., J. Biol. Chem., vol. 256, pp. 9750-9754, 1981.
Kung Hsiang-Fu
Miller David L.
Pestka Sidney
Dulak Norman C.
Gould George M.
Hazel Blondel
Hoffmann-La Roche Inc.
Saxe Jon S.
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