Crystalline human leukocyte interferon

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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424 85, 435811, C07K 1526, A61K 4502, C12P 2100

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active

046721088

ABSTRACT:
The crystallization of human leukocyte interferon is described. In a preferred embodiment crystalline recombinant human leukocyte interferon A (IFL-rA) is prepared.

REFERENCES:
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patent: 4197238 (1980-04-01), Murata et al.
patent: 4289690 (1981-09-01), Pestka et al.
Nagata, S., et al., Nature, vol. 284, pp. 316-320, 1980.
Rubenstein, M., et al., Proc. Natl. Acad. Sci., vol. 76, pp. 640-644, 1979.
McPherson, Jr., A., J. Biol. Chem., vol. 251, pp. 6300-6303, 1976.
Goeddel et al., Nature, vol. 287, pp. 411-415, 1980.
Staehelin et al., J. Biol. Chem., vol. 256, pp. 9750-9754, 1981.

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