Crystalline genistein sodium salt dihydrate

Details Crystalline genistein sodium salt dihydrate Crystalline genistein sodium salt dihydrate

2011-01-04

2011-01-04

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S403000

Reexamination Certificate

active

07863325

ABSTRACT:
The disclosure relates to a new crystalline form of genistein. The disclosed crystalline form is crystalline genistein sodium salt dihydrate. The disclosure also relates to the novel genistein salt composition represented by this crystalline form. Therapeutic compositions containing crystalline genistein sodium salt and a pharmaceutically acceptable carrier are described. The disclosure also relates to therapeutic methods comprising the step of administering to a patient in need thereof a therapeutically effective amount of a therapeutic composition containing the crystalline form of the disclosure or crystalline genistein sodium salt dihydrate.

REFERENCES:
patent: 4841077 (1989-06-01), Ito et al.
patent: 5637703 (1997-06-01), Mazurek et al.
patent: 2001/0003781 (2001-06-01), Dobbins et al.
patent: 2003/0157225 (2003-08-01), Husband et al.
patent: 2004/0023981 (2004-02-01), Ren et al.
patent: 2004/0106561 (2004-06-01), Kelly
patent: 2008/0131907 (2008-06-01), Wang et al.
patent: WO 97/06273 (1997-02-01), None
patent: WO 97/22596 (1997-06-01), None
patent: WO 97/30035 (1997-08-01), None
patent: WO 97/32856 (1997-09-01), None
patent: WO 98/13354 (1998-04-01), None
patent: WO 99/02166 (1999-01-01), None
patent: WO 00/15627 (2000-03-01), None
patent: WO 00/40529 (2000-07-01), None
patent: WO 00/41669 (2000-07-01), None
patent: WO 02/04434 (2001-01-01), None
patent: WO 01/92224 (2001-12-01), None
patent: WO 02/08213 (2002-01-01), None
patent: WO 2004/058781 (2004-07-01), None
patent: WO 2007/064254 (2007-05-01), None
patent: WO 2010/068861 (2010-06-01), None
Akiyama et al., J. Biol. Chem. (1987) vol. 262, pp. 5592-5595.
Gilman et al. (Ed.),Goodman and Gilman's“The Pharmacological Basis of Therapeutics” (2001, 10thed.) McGraw Hit Press, pp. 155-173.
Grynkiewicz et al., “X-ray and13C CP MAS Investigations of Structure of Two Genistein Derivatives,”J .Mol. Struct.(2004) vol. 694, p. 121.
Hakansson and Allen,FEBS Lett.(1995) vol. 372, pp. 238-242.
Huang et al.,J. Biol. Chem.(1992) vol. 267, pp. 15511-15515.
lgarashi and Komiya,J. Neurosci. Res.(1991) vol. 30, pp. 266-274.
Kozerski et al., “Solution and Solid State13C NMR and X-ray Studies of Genistein Complexes with Amines. Potential Biological Function of the C-7, C-5, and C-4-OH Groups,”Org. Biomol. Chem.(2003) vol. 1, p. s3578.
Li and Sarkar,Cancer Lett.(2002) vol. 186, p.157.
Mazurek et al., “Genistein Complexes with Arnines: Structure and Properties,”J. Chem. Soc., Perkin Trans.(1998) vol. 2, p. 1223.
O'Dell et al.,Nature(1991) vol. 353, pp. 558-560.
Remington's Pharmaceutical Sciences,(1990, 18thEd.) Mack Publishing Co.
Wietrzyk et al.,Anticancer Res.(2001) vol. 12, pp. 3893-3896.
Zhang et al.,Acta Crystallographica(2006) Section C, Crystal Structure Communications, C62, m484-m487.
International Search Report, International Application No. PCT/US2009/067664 (corresponding to instant application No. 12/636,395), dated Mar. 2, 2010 (Lee W. Young).
Written Opinion of the International Searching Authority, International Application No. PCTILIS2009/67664 (corresponding to instant application No. 12/636,395), dated Mar. 2, 2010 (Lee W. Young).

Affiliated with

Also associated with

Rating

Crystalline genistein sodium salt dihydrate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystalline genistein sodium salt dihydrate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline genistein sodium salt dihydrate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2741227