Crystalline FRAP complex

Details Crystalline FRAP complex Crystalline FRAP complex

1997-10-31

1999-08-17

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 231, 536 235, C07K 1447

Patent

active

059395281

ABSTRACT:
The invention relates to the human protein FRAP, and in particular to the FKBP12-rapamycin binding domain thereof and to the ternary complex formed by the FRB domain, rapamycin and FKBP12. A new crystalline composition comprising the ternary complex, coordinates defining its three dimensional structure in atomic detail, and uses thereof are disclosed.

REFERENCES:
Choi et al. "Structure of the FKBP12-Rapamycin complex interacting with the binding domain of human FRAP" Science 273, 239-242, Jul. 12, 1996.
Van Duyne "Atomic structure of the human immunophilin FKBP-12 complex with FK506 and rapamycin" J. Mol. Biol. 229, 105-124, 1993.
Wilson et al. Comparative X-ray structure of the major binding protein for the immunosuppressant FK506 . . . Acta Cryst. D51, 551-521, 1995.

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