Crystalline forms of solvated ilaprazole

Details Crystalline forms of solvated ilaprazole Crystalline forms of solvated ilaprazole

2011-08-02

2011-08-02

Morris, Patricia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07989632

ABSTRACT:
The invention relates to crystalline forms of various solvates of ilaprazole, 2[[(4-methoxy-3-methyl-2-pyridinyl)-methyl]sulfinyl]-5-(1H-pyrrol-1-yl)1H-Benzimidazole. The invention also relates to a pharmaceutical composition for inhibiting gastric acid secretion comprising crystalline ilaprazole hydrate according to the invention in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier. The invention also provides methods of treatment for various acid-related gastrointestinal (GI) disorders.

REFERENCES:
patent: 6627646 (2003-09-01), Bakale et al.
patent: WO 95/23140 (1995-08-01), None
patent: WO 2006/099810 (2006-09-01), None
patent: WO 2006/118534 (2006-11-01), None
Kil et al., “Comparison of, etc.,” Journal of Autonmic Pharmacology, 2000, 20, 291-296.
Vippagunta et al., “Crystalline solids”, Advanced Drug Delivery Reviews 48 (2001) 3-26.
Silverman, The Organic Chemistry of Drug Design and Drug Action, NY: Academic Press, Inc. 1993, 72-76.
Rowland and Tozer. “Clinical Pharmacokinetics, etc.,” 1995, p. 123.
Wilbraham et al. “Organic and biochemistry . . . ” p. 250-251 (1985).
Garattini “Active drug metabolites . . . ” Clin. Pharmacokinetics v.10, p. 216-227 (1985).
CMU Pharmaceutical polymorphism, intenet p. 1-3 (2002) (printout Apr. 3, 2008).
Singhal et al., “Drug polymorphism, etc., ”Advanced drug delivery reviews 56, 335-347 (2004).
Concise Encyclopedia, NY: Walter de Gruyter Berlin, 1994, 872-873.
Brittain ed., “Polymorphism, etc.,” NY:Marcel Dekker, Inc., 1999, 1-2, 183-226, 235-238.
Jain et al., “Polymorphism in Pharmacy”, Indian Drugs, 1986, 23(6) 315-329.
Ulicky. Comprehensive Dictionary of Physical Chemistry, NY: Prentice Hall, 1992, p. 21.
Muzaffar et al., “Polymorphism and Drug Availability, etc.,” J of Pharm. (Lahore), 1979, 1(1), 59-66.
U.S. Pharmacopia #23, National Formulary #18, 1995, 1843-1844.
Caira, “Crystalline Polymorphism, etc.,” Topics in Current Chemistry, 198, Springer Verlag Berlin Heidelberg 1998, 163-208.
Doelker, english translation of S.T.P, Pratiques (1999), 9(5), 399-409, pp. 1033.
International Search Report for PCT/US2007/089137 dated May 15, 2008.
Kim et al., “IY-81149: Antiulcerative H+/K+-ATPase Inhibitor,”Drugs of the Future, 24(6), 618-621, 1999.

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