Crystalline forms of rapamycin analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C540S456000

Reexamination Certificate

active

07812032

ABSTRACT:
A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, or combination thereof:

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Wagner et al, “Rapamycin Analogs With Reduced Systemic Exposure” Bioorganic & Medicinal Chemistry Letters 2005.
Pagano, Thomas G. “Spectral Assignments and Reference Data”, Magnetic Resonance in Chemistry, Dec. 13, 2004.
European Search Reprot for 07799771.6, mailed Sep. 23, 2009, 7 pgs.

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