Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reissue Patent
2002-09-20
2009-06-23
Berch, Mark L (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reissue Patent
active
RE040794
ABSTRACT:
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5alcohol at between −5 and −25° C.
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Brands Karel M. J.
Crocker Louis S.
Cvetovich Raymond
Fisher Elizabeth S.
Jobson Ronald
Berch Mark L
Heber Sheldon O.
Merck & Co. , Inc.
Walton Kenneth R.
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