Crystalline forms of antibiotic side chain intermediates

Details Crystalline forms of antibiotic side chain intermediates Crystalline forms of antibiotic side chain intermediates

2001-02-28

2002-11-12

Gerstl, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06479667

ABSTRACT:

BACKGROUND OF THE INVENTION
Crystalline forms of intermediates for carbapenem antibiotics are desirable from a stability and purity standpoint. These compounds facilitate the synthesis of carbapenem antibiotics on a commercial scale.
In the present invention, crystalline forms of the compound 2S-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]-amino] benzoic acid have been discovered and characterized. Crystalline 2S-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]-amino]benzoic acid and salts and solvates thereof are disclosed. The compounds can generally be synthesized taking into account the disclosure of U.S. Pat. No. 5,648,501 granted Jul. 15, 1997 and U.S. Pat. No. 5,963,747, granted Oct. 12, 1999 (both incorporated herein by reference).
SUMMARY OF THE INVENTION
Crystalline 2S-cis-3-[[(4-mercapto-2-pyrrolidinyl) carbonyl]-amino]benzoic acid as well as salts and solvates thereof are disclosed.


REFERENCES:
patent: 5648501 (1997-07-01), Brands
patent: 5965747 (1999-10-01), Brands et al.
patent: 6063931 (2000-05-01), Brands et al.
patent: WO 97/06154 (1997-02-01), None

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