Crystalline forms of a factor Xa inhibitor

Details Crystalline forms of a factor Xa inhibitor Crystalline forms of a factor Xa inhibitor

2008-05-13

2008-05-13

Seaman, Margaret D. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11302692

ABSTRACT:
The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.

REFERENCES:
patent: 6967208 (2005-11-01), Pinto et al.
patent: 2003/0191115 (2003-10-01), Pinto et al.
patent: 03/026652 (2003-03-01), None
patent: WO 2006/036927 (2006-04-01), None
U.S. Appl. No. 11/234,942, filed Sep. 26, 2005, Zhang et al.
U.S. Appl. No. 11/235,647, filed Sep. 26, 2005, Mudryk et al.
U.S. Appl. No. 11/235,731, filed Sep. 26, 2005, Zhang et al.
Elodi, S. et al., “Optimization of Conditions for the Catalytic Effect of The Factor IXa—Factor VII Complex: Probable role of the complex in the amplification of blood coagulation”, Thrombosis Research, vol. 15, pp. 617-629 (1979).

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