Crystalline form V of agomelatine, a process for its...

Details Crystalline form V of agomelatine, a process for its... Crystalline form V of agomelatine, a process for its...

2008-04-15

2008-04-15

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S617000

Reexamination Certificate

active

07358395

ABSTRACT:
Crystalline form V of the compound of formula (I):characterised by its powder X-ray diffraction diagram.Medicinal products containing the same which are useful in the treatment of melatoninergic disorders.

REFERENCES:
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patent: 0447285 (1991-09-01), None
patent: 1564202 (2005-08-01), None
Tinant, B. et al., “N-[2-(7-methoxy-1-naphthyl)ethyl]acetamid E, a potent melatonin analog” ACTA Crystallographic section C. Crystal structure communications, vol. C50, No. 6, p. 907-910, 1994.
Depreux, P., et al., “Synthesis and structure-activity relationship of novel naphthalenic and bioisosteric amidic derivatives as melatonin receptor ligands” Journal of Medicinal Chemistry, vol. 37, No. 20, p. 3231-3239, 1994.
Chilman-Blair, K., et al., “Agomelatine antidepressant treatment of bipolar disorder melatonin agonist/5-HT20 antagonist” Durgs of the Future, vol. 28, No. 1, p. 7-13, 2003.
Preliminary Search Report for FR 0508278 of Jun. 26, 2006.

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