Crystalline form of the catalytic domain of Aurora 2 kinase...

Details Crystalline form of the catalytic domain of Aurora 2 kinase... Crystalline form of the catalytic domain of Aurora 2 kinase...

2004-09-17

2008-09-09

Steadman, David J (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C436S004000

Reexamination Certificate

active

07422885

ABSTRACT:
The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.

REFERENCES:
patent: WO 03/031606 (2003-04-01), None
patent: WO 03/092607 (2003-11-01), None
McPherson, Eur. J. Biochem. 189:1-23, 1990.
Skarzynski et al., Acta Crystallogr D Biol Crystallogr D62:102-107, 2006.
Branden et al.; “Introduction to Protein Structure Second Edition”, Garland Publishing Inc., New York, 1999, pp. 374, 375, 382.
Drenth, “Principles of X-ray Crystallography,” Springer, New York, 1995, p. 1.
Kierzek et al., Biophys Chem 91:1-20, 2001.
Bayliss et al., “Structural basis of Aurora-A activation by TPX2 at the mitotic spindle,”Mol Cell, 12(4):851-862 (2003).
Cheetham et al., “Crystal structure of aurora-2, an oncogenic serine/threonine kinase,”J Biol Chem, 277(45):42419-42422 (2002); Epub Sep. 16, 2002.
Nowakowski et al., “Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography,”Structure(Camb), 10(12):1659-1667 (2002).

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