Crystalline form of a vitamin D analogue

Details Crystalline form of a vitamin D analogue Crystalline form of a vitamin D analogue

2007-06-26

2007-06-26

Badio, Barbara P. (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

C552S653000

Reissue Patent

active

10986575

ABSTRACT:
The present invention relates to calcipotriol hydrate—a new crystalline form of calcipotriol—with superior technical properties and with superior stability.

REFERENCES:
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patent: 4866048 (1989-09-01), Calverley et al.
patent: 5292727 (1994-03-01), Godtfredsen
patent: 59-104358 (1984-06-01), None
patent: WO8700834 (1987-02-01), None
Thavarajah et al. “1,25(OH)2D3 and Calcipotriol (MC903) have similar effects on the induction of osteoclast-like cell formation in human bone marrow cultures”. Biochemical and Biophysical Research Communications, vol. 171, No. 3, Sep. 28, 1990, pp. 1056-1063.
Bagot et al., “Immunosuppressive effects of 1,25-dihydroxyvitamin D3 analog (Calcipotriol) on epidermal cells”. Chemical Abstracts, vol. 119, No. 5, Aug. 2, 1993, Abstract No. 41719, p. 182, col. 1, see abstract and Proc. Workshop Vitamin D (8th) 1991, pp. 518-519.
Braeutigam et al., “Effects of calcipotriol (MC903) and calcitriol after topical application on the skin of hairless rats. Much lower effect of calcipotriol on systemic calcium homeostasis”. Chemical Abstracts vol. 117, No. 21, Nov. 23, 1992, abstract #205159, p. 93, col. 1, see abstract & Skin Pharmacol. vol. 5, No. 2, 1992, pp. 87-92.
Kragblle et al., “Vitamin D analogs in the treatment of psoriasis”. Chemical Abstracts, vol. 116, No. 25, Jun. 22, 1992, abstract No. 248622, p. 90, col. 1, see abstract & J. Cell. Biochem. vol. 49, No. 1, 1992, pp. 46-52.
Larsen et al., “Structure and absolute configuration of a monohydrate of calcipotriol (1.alpha.,3,5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol”, Acta Crystallographica, Section C, Crystal Structure Communications, vol. 49, No. 3, 1993, pp. 618-621, see the whole document.

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